Production moving out of California, the intangible nature of good scripts and material, the shifting tide of audience mores and desires... Audrey Hepburn got these answers right back in 1963. Journalists and others are still fixated on these issues - see the recent Tarantino interview where Lane Brown expects him to comment on industry trends.
Numb minds seem to expect artists to be some form of Tasseographer, but like Hepburn says, creators are compelled to follow their instincts. To make something from nothing is a drive that exists outside of rational predictions and shrewd calculations. Memorable creators, like Hepburn and Tarantino, driven by instinctive, emotional imperatives will always lead those that chase certainty.